This study integrates evidence on the effectiveness of interventions within early childhood education and care (ECEC) settings that aimed to promote the development of creativity in young children, from birth to six years of age. We explored 44 studies based on 5,817 children. A total of nine creativity domains (i.e., originality, fluency, imagination, creativity total score, elaboration, pretend play, flexibility, creative characteristics, and curiosity and exploration) were found across studies in the systematic review. Of these creativity domains, eight were included in the meta-analysis. Findings suggest that creativity can be effectively fostered through structured, intentional interventions, particularly those implemented in small groups, that incorporate drawing and imaginative tasks and are situated in well-designed learning environments. To support the development of children’s creativity in ECEC settings, educators and curriculum designers are encouraged to integrate arts-based, hands-on activities that promote elaboration and imaginative thinking.